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PUBLICATIONS

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Unique Allergic Asthma Phenotypes in Offspring of House Dust Mite Exposed Mice.
Lebold KM, Drake MG, Pincus AB, Pierce AB, Fryer AD, Jacoby DB.
Am J Respir Cell Mol Biol. 2022 Apr 1. Online ahead of print. PMID: 35363997

pubmed.ncbi.nlm.nih.gov/35363997/


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​Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity.
Pincus AB, Huang SJ, Lebold KM, De La Torre U, Proskocil BJ, Drake MG, Nakai H, Fryer AD, Jacoby DB.
Sci Rep. 2022 Mar 23;12(1):5006. PMID: 35322058

pubmed.ncbi.nlm.nih.gov/35322058/


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Metformin prevents airway hyperreactivity in rats with dietary obesity.
Calco GN, Proskocil BJ, Jacoby DB, Fryer AD, Nie Z.Am J Physiol Lung Cell Mol Physiol. 2021 Oct 20. PMID: 34668415

pubmed.ncbi.nlm.nih.gov/34668415/


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Airway Sensory Nerve Plasticity in Asthma and Chronic Cough.
Drake MG, Cook M, Fryer AD, Jacoby DB, Scott GD.Front Physiol. 2021 Sep 7;12:720538. PMID: 34557110

pubmed.ncbi.nlm.nih.gov/34557110/


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Eosinophils in Health and Disease: A State-of-the-Art Review.
Wechsler ME, Munitz A, Ackerman SJ, Drake MG, Jackson DJ, Wardlaw AJ, Dougan SK, Berdnikovs S, Schleich F, Matucci A, Chanez P, Prazma CM, Howarth P, Weller PF, Merkel PA.Mayo Clin Proc. 2021 Oct;96(10):2694-2707. PMID: 34538424

pubmed.ncbi.nlm.nih.gov/34538424/


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TLR7 is expressed by support cells, but not sensory neurons, in ganglia.
Proskocil BJ, Wai K, Lebold KM, Norgard MA, Michaelis KA, De La Torre U, Cook M, Marks DL, Fryer AD, Jacoby DB, Drake MG. J Neuroinflammation. 2021 Sep 16;18(1):209. PMID: 34530852

pubmed.ncbi.nlm.nih.gov/34530852/


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Pioglitazone prevents obesity-related airway hyperreactivity and neuronal M2 receptor dysfunction.
Proskocil BJ, Fryer AD, Jacoby DB, Nie Z.Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L236-L247. PMID: 34009030

pubmed.ncbi.nlm.nih.gov/34009030/


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Insulin acutely increases agonist-induced airway smooth muscle contraction in humans and rats.
Becky J Proskocil, Gina N Calco, Zhenying Nie. Am J Physiol Lung Cell Mol Physiol 2021 Apr 1;320(4):L545-L556. PMID: 33501891

pubmed.ncbi.nlm.nih.gov/33501891/


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Mini review: Neural mechanisms underlying airway hyperresponsiveness.
​Pincus AB, Fryer AD, Jacoby DB.Neurosci Lett. 2021 Mar 2;751:135795. PMID: 33667601
​
pubmed.ncbi.nlm.nih.gov/33667601/


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Airway Sensory Nerve Density Is Increased in Chronic Cough.
Shapiro CO, Proskocil BJ, Oppegard LJ, Blum ED, Kappel NL, Chang CH, Fryer AD, Jacoby DB, Costello RW, Drake MG. Am J Respir Crit Care Med. 2021 Feb 1;203(3):348-355.
​
PMID: 32809840
​
pubmed.ncbi.nlm.nih.gov/32809840/


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Interactions of Eosinophils with Nerves.
Drake MG, Proskocil BJ, Nie Z.Methods Mol Biol. 2021;2241:161-181. PMID: 33486736

​pubmed.ncbi.nlm.nih.gov/33486736/


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Unraveling the connection between eosinophils and obesity.
Calco GN, Fryer AD, Nie Z.J Leukoc Biol. 2020 Jul;108(1):123-128. PMID: 32170879

pubmed.ncbi.nlm.nih.gov/32170879/


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Transient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGE2.
Marsh BJ, Fryer AD, Jacoby DB, Drake MG.Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L943-L952. PMID: 32233794

​pubmed.ncbi.nlm.nih.gov/32233794/


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Optogenetic Control of Airway Cholinergic Neurons In Vivo.
Pincus AB, Adhikary S, Lebold KM, Fryer AD, Jacoby DB.Am J Respir Cell Mol Biol. 2020 Apr;62(4):423-429. PMID: 31899655

​pubmed.ncbi.nlm.nih.gov/31899655/


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IL-5 Exposure In Utero Increases Lung Nerve Density and Airway Reactivity in Adult Offspring.
Lebold KM, Drake MG, Hales-Beck LB, Fryer AD, Jacoby DB.Am J Respir Cell Mol Biol. 2020 Apr;62(4):493-502. PMID: 31821769

pubmed.ncbi.nlm.nih.gov/31821769/


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Inflammatory mechanisms linking maternal and childhood asthma.
Lebold KM, Jacoby DB, Drake MG.J Leukoc Biol. 2020 Jul;108(1):113-121. PMID: 32040236

pubmed.ncbi.nlm.nih.gov/32040236/


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Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice.
Nie Z, Maung JN, Jacoby DB, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L242-L251. PMID: 31746625

pubmed.ncbi.nlm.nih.gov/31746625/


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Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells.
Proskocil BJ, Grodzki ACG, Jacoby DB, Lein PJ, Fryer AD.Am J Respir Cell Mol Biol. 2019 Nov;61(5):620-630. PMID: 30978295

pubmed.ncbi.nlm.nih.gov/30978295/


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Eosinophils increase airway sensory nerve density in mice and in human asthma.
Drake MG, Scott GD, Blum ED, Lebold KM, Nie Z, Lee JJ, Fryer AD, Costello RW, Jacoby DB.Sci Transl Med. 2018 Sep 5;10(457):eaar8477. PMID: 30185653

pubmed.ncbi.nlm.nih.gov/30185653/


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Eosinophil and airway nerve interactions in asthma.
Drake MG, Lebold KM, Roth-Carter QR, Pincus AB, Blum ED, Proskocil BJ, Jacoby DB, Fryer AD, Nie Z.J Leukoc Biol. 2018 Jul;104(1):61-67. PMID: 29633324

pubmed.ncbi.nlm.nih.gov/29633324/


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Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.
Shaffo FC, Grodzki AC, Fryer AD, Lein PJ.Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L485-L501. PMID: 29952220

pubmed.ncbi.nlm.nih.gov/29952220/


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Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-α blockade.
Wicher SA, Lawson KL, Jacoby DB, Fryer AD, Drake MG.Physiol Rep. 2017 Dec;5(24):e13538. PMID: 29242307

pubmed.ncbi.nlm.nih.gov/29242307/


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Virus-induced asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of asthma.
Skappak C, Ilarraza R, Wu YQ, Drake MG, Adamko DJ.PLoS One. 2017 Jul 24;12(7):e0181425. PMID: 28742120

pubmed.ncbi.nlm.nih.gov/28742120/


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Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs.
Wicher SA, Jacoby DB, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L969-L982. PMID: 28258108

pubmed.ncbi.nlm.nih.gov/28258108/


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Protective Role of Eosinophils and TNFa after Ozone Inhalation.
Fryer AD, Jacoby DB, Wicher SA.Res Rep Health Eff Inst. 2017 Mar;(191):1-41. PMID: 29659241

pubmed.ncbi.nlm.nih.gov/29659241/


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Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus.
Drake MG, Bivins-Smith ER, Proskocil BJ, Nie Z, Scott GD, Lee JJ, Lee NA, Fryer AD, Jacoby DB. Am J Respir Cell Mol Biol. 2016 Sep;55(3):387-94. PMID: 27049514

pubmed.ncbi.nlm.nih.gov/27049514/


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TLR7 agonist-induced bronchodilation: key mechanistic questions remain.
Drake MG. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L177. PMID: 27407079

pubmed.ncbi.nlm.nih.gov/27407079/


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Toll-Like Receptor 7-Targeted Therapy in Respiratory Disease.
Lebold KM, Jacoby DB, Drake MG. Transfus Med Hemother. 2016 Mar;43(2):114-9.
​
PMID: 27226793

https://pubmed.ncbi.nlm.nih.gov/27226793/


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The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity.
Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD.Am J Respir Cell Mol Biol. 2015 Nov;53(5):738-47. PMID: 25897622

pubmed.ncbi.nlm.nih.gov/25897622/


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Interleukin-1β mediates virus-induced m2 muscarinic receptor dysfunction and airway hyperreactivity.
Rynko AE, Fryer AD, Jacoby DB.Am J Respir Cell Mol Biol. 2014 Oct;51(4):494-501. PMID: 24735073

https://pubmed.ncbi.nlm.nih.gov/24735073/


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Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice.
Lee JJ, Protheroe CA, Luo H, Ochkur SI, Scott GD, Zellner KR, Raish RJ, Dahl MV, Vega ML, Conley O, Condjella RM, Kloeber JA, Neely JL, Patel YS, Maizer P, Mazzolini A, Fryer AD, Jacoby NW, Jacoby DB, Lee NA.J Allergy Clin Immunol. 2015 Feb;135(2):477-87. 
PMID: 25129680

pubmed.ncbi.nlm.nih.gov/25129680/


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Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats.
Nie Z, Jacoby DB, Fryer AD.Am J Respir Cell Mol Biol. 2014 Aug;51(2):251-61. PMID: 24605871

pubmed.ncbi.nlm.nih.gov/24605871/


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Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways.
Scott GD, Blum ED, Fryer AD, Jacoby DB.Am J Respir Cell Mol Biol. 2014 Jul;51(1):43-55. PMID: 24471696

pubmed.ncbi.nlm.nih.gov/24471696/


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Interactions of eosinophils with nerves.
Roth-Carter QR, Jacoby DB, Nie Z.Methods Mol Biol. 2014;1178:215-29. PMID: 24986620

​pubmed.ncbi.nlm.nih.gov/24986620/


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Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs.
Verhein KC, Salituro FG, Ledeboer MW, Fryer AD, Jacoby DB.PLoS One. 2013 Sep 18;8(9):e75351. PMID: 24058677

​pubmed.ncbi.nlm.nih.gov/24058677/


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Toll-like receptor 7 rapidly relaxes human airways.
Drake MG, Scott GD, Proskocil BJ, Fryer AD, Jacoby DB, Kaufman EH.Am J Respir Crit Care Med. 2013 Sep 15;188(6):664-72. PMID: 23924358

​pubmed.ncbi.nlm.nih.gov/23924358/


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Toll-like receptor-2/6 and Toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs.
Drake MG, Evans SE, Dickey BF, Fryer AD, Jacoby DB.Am J Respir Cell Mol Biol. 2013 Jun;48(6):790-6. PMID: 23449736

pubmed.ncbi.nlm.nih.gov/23449736/


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Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.
Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2013;304(8):L519-29. PMID: 23377347

pubmed.ncbi.nlm.nih.gov/23377347/


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The therapeutic potential of Toll-like receptor 7 stimulation in asthma.
Drake MG, Kaufman EH, Fryer AD, Jacoby DB.Inflamm Allergy Drug Targets. 2012 Dec;11(6):484-91. PMID: 23078048

pubmed.ncbi.nlm.nih.gov/23078048/


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Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.
Scott GD, Fryer AD, Jacoby DB.Am J Respir Cell Mol Biol. 2013 Jan;48(1):10-6. PMID: 23103997

​pubmed.ncbi.nlm.nih.gov/23103997/


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Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma.
Buels KS, Jacoby DB, Fryer AD.Br J Pharmacol. 2012 Mar;165(5):1501-14. PMID: 21871018

​pubmed.ncbi.nlm.nih.gov/21871018/


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β2-Agonists inhibit TNF-α-induced ICAM-1 expression in human airway parasympathetic neurons.
Nie Z, Fryer AD, Jacoby DB.PLoS One. 2012;7(9):e44780. PMID: 23049757

​pubmed.ncbi.nlm.nih.gov/23049757/


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Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
Koguchi Y, Buenafe AC, Thauland TJ, Gardell JL, Bivins-Smith ER, Jacoby DB, Slifka MK, Parker DC.PLoS One. 2012;7(2):e31296. PMID: 22363608

pubmed.ncbi.nlm.nih.gov/22363608/


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Role of parasympathetic nerves and muscarinic receptors in allergy and asthma.
Scott GD, Fryer AD.Chem Immunol Allergy. 2012;98:48-69. PMID: 22767057

pubmed.ncbi.nlm.nih.gov/22767057/


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Muscarinic receptor agonists and antagonists: effects on inflammation and immunity.
Verbout NG, Jacoby DB. Handb Exp Pharmacol. 2012;(208):403-27. PMID: 22222708

​pubmed.ncbi.nlm.nih.gov/22222708/


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Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M₂ muscarinic receptor dysfunction.
Nie Z, Scott GD, Weis PD, Itakura A, Fryer AD, Jacoby DB.Br J Pharmacol. 2011 Sep;164(2b):444-52. PMID: 21457223

pubmed.ncbi.nlm.nih.gov/21457223/


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Eosinophils increase neuron branching in human and murine skin and in vitro.
Foster EL, Simpson EL, Fredrikson LJ, Lee JJ, Lee NA, Fryer AD, Jacoby DB.PLoS One. 2011;6(7):e22029. PMID: 21811556

​pubmed.ncbi.nlm.nih.gov/21811556/


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Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs.
Kaufman EH, Fryer AD, Jacoby DB.J Allergy Clin Immunol. 2011 Feb;127(2):462-9. PMID: 21167577

pubmed.ncbi.nlm.nih.gov/21167577/


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Three days after a single exposure to ozone, the mechanism of airway hyperreactivity is dependent on substance P and nerve growth factor.
Verhein KC, Hazari MS, Moulton BC, Jacoby IW, Jacoby DB, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L176-84. PMID: 21056958

pubmed.ncbi.nlm.nih.gov/21056958/


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Human mucosal associated invariant T cells detect bacterially infected cells.
Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, Delepine J, Winata E, Swarbrick GM, Chua WJ, Yu YY, Lantz O, Cook MS, Null MD, Jacoby DB, Harriff MJ, Lewinsohn DA, Hansen TH, Lewinsohn DM. PLoS Biol. 2010 Jun 29;8(6):e1000407. PMID: 20613858
​

pubmed.ncbi.nlm.nih.gov/20613858/


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Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms.
Proskocil BJ, Bruun DA, Thompson CM, Fryer AD, Lein PJ.PLoS One. 2010 May 10;5(5):e10562. PMID: 20479945

pubmed.ncbi.nlm.nih.gov/20479945/


2000 - 2009


Neural control of airway inflammation.
Verhein KC, Fryer AD, Jacoby DB.Curr Allergy Asthma Rep. 2009 Nov;9(6):484-90. PMID: 19814922

​pubmed.ncbi.nlm.nih.gov/19814922/



Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects.
Moreno-Vinasco L, Verbout NG, Fryer AD, Jacoby DB.Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6. PMID: 19465517

pubmed.ncbi.nlm.nih.gov/19465517/


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Atropine-enhanced, antigen challenge-induced airway hyperreactivity in guinea pigs is mediated by eosinophils and nerve growth factor.
Verbout NG, Jacoby DB, Gleich GJ, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L228-37. PMID: 19447892
​
​pubmed.ncbi.nlm.nih.gov/19447892/


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Etanercept prevents airway hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.
Nie Z, Jacoby DB, Fryer AD.Br J Pharmacol. 2009 Jan;156(1):201-10. PMID: 19134001

pubmed.ncbi.nlm.nih.gov/19134001/


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Characterization of side population cells from human airway epithelium.
Hackett TL, Shaheen F, Johnson A, Wadsworth S, Pechkovsky DV, Jacoby DB, Kicic A, Stick SM, Knight DA.Stem Cells. 2008 Oct;26(10):2576-85. PMID: 18653771

​pubmed.ncbi.nlm.nih.gov/18653771/


IL-1 receptors mediate persistent, but not acute, airway hyperreactivity to ozone in guinea pigs.
Verhein KC, Jacoby DB, Fryer AD.Am J Respir Cell Mol Biol. 2008 Dec;39(6):730-8. PMID: 18617681
​
pubmed.ncbi.nlm.nih.gov/18617681/


Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity.
Proskocil BJ, Bruun DA, Lorton JK, Blensly KC, Jacoby DB, Lein PJ, Fryer AD.Environ Health Perspect. 2008 Mar;116(3):381-8. PMID: 18335107

​pubmed.ncbi.nlm.nih.gov/18335107/


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Expression and regulation of intercellular adhesion molecule-1 on airway parasympathetic nerves.
Nie Z, Nelson CS, Jacoby DB, Fryer AD.J Allergy Clin Immunol. 2007 Jun;119(6):1415-22. PMID: 17418379

​pubmed.ncbi.nlm.nih.gov/17418379/


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Atropine pretreatment enhances airway hyperreactivity in antigen-challenged guinea pigs through an eosinophil-dependent mechanism.
Verbout NG, Lorton JK, Jacoby DB, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1126-35. PMID: 17220376

​pubmed.ncbi.nlm.nih.gov/17220376/


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Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction.
Fryer AD, Stein LH, Nie Z, Curtis DE, Evans CM, Hodgson ST, Jose PJ, Belmonte KE, Fitch E, Jacoby DB. J Clin Invest. 2006 Jan;116(1):228-36. PMID: 16374515

​pubmed.ncbi.nlm.nih.gov/16374515/


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The changing role of eosinophils in long-term hyperreactivity following a single ozone exposure.
Yost BL, Gleich GJ, Jacoby DB, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L627-35. PMID: 15923207

pubmed.ncbi.nlm.nih.gov/15923207/


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Beta2-agonist and anticholinergic drugs in the treatment of lung disease.
Proskocil BJ, Fryer AD.Proc Am Thorac Soc. 2005;2(4):305-10; discussion 311-2. PMID: 16267353

pubmed.ncbi.nlm.nih.gov/16267353/


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Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition.
Lein PJ, Fryer AD.Toxicol Sci. 2005 Jan;83(1):166-76. doi: 10.1093/toxsci/kfi001. Epub 2004 Oct 6.PMID: 15470232

pubmed.ncbi.nlm.nih.gov/15470232/


Virus-induced asthma attacks.
Jacoby DB. J Aerosol Med. 2004 Summer;17(2):169-73. PMID: 15294068

​pubmed.ncbi.nlm.nih.gov/15294068/


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Role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction.
Lee AM, Fryer AD, van Rooijen N, Jacoby DB.Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1255-9. PMID: 15136297

pubmed.ncbi.nlm.nih.gov/15136297/


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Mechanisms of organophosphate insecticide-induced airway hyperreactivity.
Fryer AD, Lein PJ, Howard AS, Yost BL, Beckles RA, Jett DA.Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L963-9. PMID: 14704222
​
pubmed.ncbi.nlm.nih.gov/14704222/


Pathophysiology of airway viral infections.
Jacoby DB. Pulm Pharmacol Ther. 2004;17(6):333-6. PMID: 15564071

​pubmed.ncbi.nlm.nih.gov/15564071/


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Insulin regulates neuronal M2 muscarinic receptor function in the ileum of diabetic rats.
Coulson FR, Jacoby DB, Fryer AD.J Pharmacol Exp Ther. 2004 Feb;308(2):760-6. PMID: 14610235

pubmed.ncbi.nlm.nih.gov/14610235/


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Effects of eosinophils on nerve cell morphology and development: the role of reactive oxygen species and p38 MAP kinase.
Kingham PJ, McLean WG, Walsh MT, Fryer AD, Gleich GJ, Costello RW.Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L915-24. PMID: 12794004

pubmed.ncbi.nlm.nih.gov/12794004/


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Dexamethasone prevents virus-induced hyperresponsiveness via multiple mechanisms.
Moreno L, Jacoby DB, Fryer AD.Am J Physiol Lung Cell Mol Physiol. 2003 Aug;285(2):L451-5. PMID: 12716653

​pubmed.ncbi.nlm.nih.gov/12716653/


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Airway neural plasticity: the nerves they are a-changin'.
Jacoby DB. Am J Respir Cell Mol Biol. 2003 Feb;28(2):138-41. PMID: 12540480

​
​pubmed.ncbi.nlm.nih.gov/12540480/


Plasticity of cholinergic and tachykinergic nerves: the convergence of the twain.
Fryer AD, Jacoby DB.Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L907-8. PMID: 12376342

pubmed.ncbi.nlm.nih.gov/12376342/


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CD8+ T lymphocytes in viral hyperreactivity and M2 muscarinic receptor dysfunction.
Adamko DJ, Fryer AD, Bochner BS, Jacoby DB.Am J Respir Crit Care Med. 2003 Feb 15;167(4):550-6. PMID: 12411283

​pubmed.ncbi.nlm.nih.gov/12411283/


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Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation.
Sawatzky DA, Kingham PJ, Court E, Kumaravel B, Fryer AD, Jacoby DB, McLean WG, Costello RW. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1279-88. PMID: 12003784

​pubmed.ncbi.nlm.nih.gov/12003784/


Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs.
Carr MJ, Hunter DD, Jacoby DB, Undem BJ. Am J Respir Crit Care Med. 2002 Apr 15;165(8):1071-5. PMID: 11956047

​pubmed.ncbi.nlm.nih.gov/11956047/


Double-stranded RNA causes airway hyperreactivity and neuronal M2 muscarinic receptor dysfunction.
Bowerfind WM, Fryer AD, Jacoby DB.J Appl Physiol (1985). 2002 Apr;92(4):1417-22. PMID: 11896005

​pubmed.ncbi.nlm.nih.gov/11896005/


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Increased function of inhibitory neuronal M2 muscarinic receptors in trachea and ileum of diabetic rats.
Coulson FR, Jacoby DB, Fryer AD.Br J Pharmacol. 2002 Mar;135(6):1355-62. PMID: 11906948

​pubmed.ncbi.nlm.nih.gov/11906948/


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Virus-induced asthma attacks.
Jacoby DB. JAMA. 2002 Feb 13;287(6):755-61. PMID: 11851543

​pubmed.ncbi.nlm.nih.gov/11851543/


Structure of the human M(2) muscarinic acetylcholine receptor gene and its promoter.
Zhou C, Fryer AD, Jacoby DB. Gene. 2001 Jun 13;271(1):87-92. PMID: 11410369

​pubmed.ncbi.nlm.nih.gov/11410369/


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Selective muscarinic receptor antagonists for airway diseases.
Lee AM, Jacoby DB, Fryer AD.Curr Opin Pharmacol. 2001 Jun;1(3):223-9. PMID: 11712743

pubmed.ncbi.nlm.nih.gov/11712743/


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Effects of dexamethasone on antigen-induced airway eosinophilia and M(2) receptor dysfunction.
Evans CM, Jacoby DB, Fryer AD.Am J Respir Crit Care Med. 2001 May;163(6):1484-92. PMID: 11371422

pubmed.ncbi.nlm.nih.gov/11371422/


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Anticholinergic therapy for airway diseases.
Jacoby DB, Fryer AD.Life Sci. 2001 Apr 27;68(22-23):2565-72. PMID: 11392627

​pubmed.ncbi.nlm.nih.gov/11392627/


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Glucocorticoid treatment increases inhibitory m(2) muscarinic receptor expression and function in the airways.
Jacoby DB, Yost BL, Kumaravel B, Chan-Li Y, Xiao HQ, Kawashima K, Fryer AD.Am J Respir Cell Mol Biol. 2001 Apr;24(4):485-91. PMID: 11306443

pubmed.ncbi.nlm.nih.gov/11306443/


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Eosinophil recruitment to the airway nerves.
Jacoby DB, Costello RM, Fryer AD.J Allergy Clin Immunol. 2001 Feb;107(2):211-8. PMID: 11174183

​pubmed.ncbi.nlm.nih.gov/11174183/


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Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction.
Evans CM, Belmonte KE, Costello RW, Jacoby DB, Gleich GJ, Fryer AD. Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L477-86. PMID: 10956622

​pubmed.ncbi.nlm.nih.gov/10956622/


Inhibition of neuronal M(2) muscarinic receptor function in the lungs by extracellular nitric oxide.
Golkar L, Yarkony KA, Fryer AD.Br J Pharmacol. 2000 Sep;131(2):312-8. PMID: 10991925

pubmed.ncbi.nlm.nih.gov/10991925/


Eosinophils and airway nerves in asthma.
Costello RW, Jacoby DB, Gleich GJ, Fryer AD. Histol Histopathol. 2000 Jul;15(3):861-8. PMID: 10963130

​pubmed.ncbi.nlm.nih.gov/10963130/


Picture

Effects of neurokinin receptor antagonists in virus-infected airways.
Jacoby DB, Yost BL, Elwood T, Fryer AD. Am J Physiol Lung Cell Mol Physiol. 2000 Jul;279(1):L59-65. PMID: 10893203

​pubmed.ncbi.nlm.nih.gov/10893203/


1990-1999


Ovalbumin sensitization changes the inflammatory response to subsequent parainfluenza infection. Eosinophils mediate airway hyperresponsiveness, m(2) muscarinic receptor dysfunction, and antiviral effects.
Adamko DJ, Yost BL, Gleich GJ, Fryer AD, Jacoby DB.J Exp Med. 1999 Nov 15;190(10):1465-78. PMID: 10562321

pubmed.ncbi.nlm.nih.gov/10562321/


Picture

Ozone-induced hyperresponsiveness and blockade of M2 muscarinic receptors by eosinophil major basic protein.
Yost BL, Gleich GJ, Fryer AD.J Appl Physiol (1985). 1999 Oct;87(4):1272-8. PMID: 10517752

pubmed.ncbi.nlm.nih.gov/10517752/


Interaction of viral infections with muscarinic receptors.
Jacoby DB, Fryer AD.Clin Exp Allergy. 1999 Jun;29 Suppl 2:59-64. PMID: 10421824

​pubmed.ncbi.nlm.nih.gov/10421824/


Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils.
Costello RW, Evans CM, Yost BL, Belmonte KE, Gleich GJ, Jacoby DB, Fryer AD.Am J Physiol. 1999 May;276(5):L709-14. PMID: 10330026

​pubmed.ncbi.nlm.nih.gov/10330026/


Effects of inflammatory cells on neuronal M2 muscarinic receptor function in the lung.
Fryer AD, Adamko DJ, Yost BL, Jacoby DB. Life Sci. 1999;64(6-7):449-55. PMID: 10069509

​pubmed.ncbi.nlm.nih.gov/10069509/


Picture

Methacholine causes reflex bronchoconstriction.
Wagner EM, Jacoby DB.J Appl Physiol (1985). 1999 Jan;86(1):294-7. PMID: 9887142

​pubmed.ncbi.nlm.nih.gov/9887142/


Picture

Muscarinic receptors and control of airway smooth muscle.
Fryer AD, Jacoby DB.Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 3):S154-60. PMID: 9817739

​pubmed.ncbi.nlm.nih.gov/9817739/


Role of insulin in antigen-induced airway eosinophilia and neuronal M2 muscarinic receptor dysfunction.
Belmonte KE, Fryer AD, Costello RW.J Appl Physiol (1985). 1998 Nov;85(5):1708-18. PMID: 980457

pubmed.ncbi.nlm.nih.gov/9804573/


Picture

Pulmonary neuronal M2 muscarinic receptor function in asthma and animal models of hyperreactivity.
Costello RW, Jacoby DB, Fryer AD.Thorax. 1998 Jul;53(7):613-6. PMID: 9797763

​pubmed.ncbi.nlm.nih.gov/9797763/


Picture

Virus- and interferon-induced loss of inhibitory M2 muscarinic receptor function and gene expression in cultured airway parasympathetic neurons.
Jacoby DB, Xiao HQ, Lee NH, Chan-Li Y, Fryer AD.J Clin Invest. 1998 Jul 1;102(1):242-8. PMID: 9649578

​pubmed.ncbi.nlm.nih.gov/9649578/


Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
Costello RW, Fryer AD, Belmonte KE, Jacoby DB.Br J Pharmacol. 1998 May;124(2):267-76. PMID: 9641542

pubmed.ncbi.nlm.nih.gov/9641542/


Role of oxidants in influenza virus-induced gene expression.
Knobil K, Choi AM, Weigand GW, Jacoby DB.Am J Physiol. 1998 Jan;274(1):L134-42. PMID: 9458811

pubmed.ncbi.nlm.nih.gov/9458811/


Picture

Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.
Evans CM, Fryer AD, Jacoby DB, Gleich GJ, Costello RW. J Clin Invest. 1997 Nov 1;100(9):2254-62. PMID: 9410903

pubmed.ncbi.nlm.nih.gov/9410903/


Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs.
Belmonte KE, Jacoby DB, Fryer AD. Br J Pharmacol. 1997 Aug;121(7):1287-94. PMID: 9257905

pubmed.ncbi.nlm.nih.gov/9257905/


Picture

Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function.
Costello RW, Schofield BH, Kephart GM, Gleich GJ, Jacoby DB, Fryer AD.Am J Physiol. 1997 Jul;273(1 Pt 1):L93-103. PMID: 9252545

​pubmed.ncbi.nlm.nih.gov/9252545/


Picture

Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways.
Fryer AD, Costello RW, Yost BL, Lobb RR, Tedder TF, Steeber DA, Bochner BS.J Clin Invest. 1997 Apr 15;99(8):2036-44. PMID: 9109449

pubmed.ncbi.nlm.nih.gov/9109449/


Role of the respiratory epithelium in asthma.
Jacoby DB. Res Immunol. 1997 Jan;148(1):48-58. PMID: 9176919

pubmed.ncbi.nlm.nih.gov/9176919/


Picture

Cultures of airway parasympathetic nerves express functional M2 muscarinic receptors.
Fryer AD, Elbon CL, Kim AL, Xiao HQ, Levey AI, Jacoby DB. Am J Respir Cell Mol Biol. 1996 Dec;15(6):716-25. PMID: 8969265

​pubmed.ncbi.nlm.nih.gov/8969265/https://pubmed.ncbi.nlm.nih.gov/8969265/


Oxidant stress responses in influenza virus pneumonia: gene expression and transcription factor activation.
Choi AM, Knobil K, Otterbein SL, Eastman DA, Jacoby DB.Am J Physiol. 1996 Sep;271(3 Pt 1):L383-91. PMID: 8843786

​​pubmed.ncbi.nlm.nih.gov/8843786/


Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung.
Kahn RM, Okanlami OA, Jacoby DB, Fryer AD.J Clin Invest. 1996 Jul 15;98(2):299-307. PMID: 8755638

pubmed.ncbi.nlm.nih.gov/8755638/


NIH conference. Airway inflammation.
Shelhamer JH, Levine SJ, Wu T, Jacoby DB, Kaliner MA, Rennard SI.Ann Intern Med. 1995 Aug 15;123(4):288-304. PMID: 7611596

​pubmed.ncbi.nlm.nih.gov/7611596/


Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure.
Subauste MC, Jacoby DB, Richards SM, Proud D. J Clin Invest. 1995 Jul;96(1):549-57. PMID: 7615827

pubmed.ncbi.nlm.nih.gov/7615827/


Eosinophil-associated inflammation in bronchial asthma: a connection to the nervous system.
Gleich GJ, Jacoby DB, Fryer AD.Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):205-7. PMID: 7542072

pubmed.ncbi.nlm.nih.gov/7542072/


Picture

Pretreatment with an antibody to interleukin-5 prevents loss of pulmonary M2 muscarinic receptor function in antigen-challenged guinea pigs.
Elbon CL, Jacoby DB, Fryer AD.Am J Respir Cell Mol Biol. 1995 Mar;12(3):320-8. PMID: 7873198

​pubmed.ncbi.nlm.nih.gov/7873198/


Ozone-induced loss of neuronal M2 muscarinic receptor function is prevented by cyclophosphamide.
Gambone LM, Elbon CL, Fryer AD.J Appl Physiol (1985). 1994 Sep;77(3):1492-9. PMID: 7836157

pubmed.ncbi.nlm.nih.gov/7836157/


The effect of leukocyte depletion on pulmonary M2 muscarinic receptor function in parainfluenza virus-infected guinea-pigs.
Fryer AD, Yarkony KA, Jacoby DB.Br J Pharmacol. 1994 Jun;112(2):588-94. PMID: 8075876

pubmed.ncbi.nlm.nih.gov/8075876/


Picture

Influenza virus induces expression of antioxidant genes in human epithelial cells.
Jacoby DB, Choi AM. Free Radic Biol Med. 1994 Jun;16(6):821-4. PMID: 8070686

pubmed.ncbi.nlm.nih.gov/8070686/


Ozone-induced airway hyperresponsiveness and loss of neuronal M2 muscarinic receptor function.
Schultheis AH, Bassett DJ, Fryer AD.J Appl Physiol (1985). 1994 Mar;76(3):1088-97. PMID: 8005850

pubmed.ncbi.nlm.nih.gov/8005850/


Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.
Jacoby DB, Gleich GJ, Fryer AD.J Clin Invest. 1993 Apr;91(4):1314-8. PMID: 8473484

pubmed.ncbi.nlm.nih.gov/8473484/


Neuronal M2 muscarinic receptor function in guinea-pig lungs is inhibited by indomethacin.
Fryer AD, Okanlami OA.Am Rev Respir Dis. 1993 Mar;147(3):559-64. PMID: 8442587

pubmed.ncbi.nlm.nih.gov/8442587/


Picture

Effect of inflammatory cell mediators on M2 muscarinic receptors in the lungs.
Fryer AD, Jacoby DB.Life Sci. 1993;52(5-6):529-36. PMID: 8441332

pubmed.ncbi.nlm.nih.gov/8441332/


Function of pulmonary M2 muscarinic receptors in antigen-challenged guinea pigs is restored by heparin and poly-L-glutamate.
Fryer AD, Jacoby DB.J Clin Invest. 1992 Dec;90(6):2292-8. PMID: 1281829

pubmed.ncbi.nlm.nih.gov/1281829/


Influenza virus A infection induces interleukin-8 gene expression in human airway epithelial cells.
Choi AM, Jacoby DB. FEBS Lett. 1992 Sep 14;309(3):327-9. PMID: 1516705

​pubmed.ncbi.nlm.nih.gov/1516705/


M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.
Fernandes LB, Fryer AD, Hirshman CA.J Pharmacol Exp Ther. 1992 Jul;262(1):119-26. PMID: 1625190

pubmed.ncbi.nlm.nih.gov/1625190/


Viral infection increases contractile but not secretory responses to substance P in ferret trachea.
Murray TC, Jacoby DB.J Appl Physiol (1985). 1992 Feb;72(2):608-11. PMID: 1373130

pubmed.ncbi.nlm.nih.gov/1373130/


Virus-induced airway hyperresponsiveness--possible involvement of neural mechanisms.
Jacoby DB, Fryer AD.Am Rev Respir Dis. 1991 Dec;144(6):1422-3. PMID: 1660232

pubmed.ncbi.nlm.nih.gov/1660232/


Dysfunction of M2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge.
Fryer AD, Wills-Karp M.J Appl Physiol (1985). 1991 Dec;71(6):2255-61. PMID: 1778920

pubmed.ncbi.nlm.nih.gov/1778920/


Picture

Infection of cultured human airway epithelial cells by influenza A virus.
Reiss TF, Gruenert DC, Nadel JA, Jacoby DB.Life Sci. 1991;49(16):1173-81. PMID: 1895875

pubmed.ncbi.nlm.nih.gov/1895875/


Parainfluenza virus infection damages inhibitory M2 muscarinic receptors on pulmonary parasympathetic nerves in the guinea-pig.
Fryer AD, Jacoby DB.Br J Pharmacol. 1991 Jan;102(1):267-71. PMID: 1646059

pubmed.ncbi.nlm.nih.gov/1646059/


Picture

Abnormalities in neural control of smooth muscle in virus-infected airways.
Jacoby DB, Fryer AD. Trends Pharmacol Sci. 1990 Oct;11(10):393-5. PMID: 2256176

pubmed.ncbi.nlm.nih.gov/2256176/


Parainfluenza virus type 1 reduces the affinity of agonists for muscarinic receptors in guinea-pig lung and heart.
Fryer AD, el-Fakahany EE, Jacoby DB.Eur J Pharmacol. 1990 May 31;181(1-2):51-8. PMID: 2167230

pubmed.ncbi.nlm.nih.gov/2167230/


Identification of three muscarinic receptor subtypes in rat lung using binding studies with selective antagonists.
Fryer AD, el-Fakahany EE.Life Sci. 1990;47(7):611-8. doi: 10.1016/0024-3205(90)90572-9.PMID: 2402185

pubmed.ncbi.nlm.nih.gov/2402185/


1984 - 1989


Different mechanisms of antagonism by methoctramine of two neuronal muscarinic receptor-mediated second messenger responses.
Lee NH, Fryer AD, Forray C, el-Fakahany EE.J Pharmacol Exp Ther. 1989 Dec;251(3):992-9. PMID: 2557423

pubmed.ncbi.nlm.nih.gov/2557423/


Picture

Parainfluenza virus infection of cultured airway epithelial cells.
Jacoby DB, Nadel JA.J Virol Methods. 1989 Nov;26(2):199-208. PMID: 2559102

pubmed.ncbi.nlm.nih.gov/2559102/


Virus induces airway hyperresponsiveness to tachykinins: role of neutral endopeptidase.
Dusser DJ, Jacoby DB, Djokic TD, Rubinstein I, Borson DB, Nadel JA.J Appl Physiol (1985). 1989 Oct;67(4):1504-11. PMID: 2477356

​pubmed.ncbi.nlm.nih.gov/2477356/


Identification of M1 muscarinic receptors in pulmonary sympathetic nerves in the guinea-pig by use of pirenzepine.
Maclagan J, Fryer AD, Faulkner D. Br J Pharmacol. 1989 Jun;97(2):499-505. PMID: 2758228

pubmed.ncbi.nlm.nih.gov/2758228/


An endogenous factor induces heterogeneity of binding sites of selective muscarinic receptor antagonists in rat heart.
Fryer AD, el-Fakahany EE.Membr Biochem. 1989;8(3):127-32. PMID: 2641948

pubmed.ncbi.nlm.nih.gov/2641948/


The effects of epithelial cell supernatant on contractions of isolated canine tracheal smooth muscle.
Barnett K, Jacoby DB, Nadel JA, Lazarus SC.Am Rev Respir Dis. 1988 Oct;138(4):780-3. PMID: 3202451

​pubmed.ncbi.nlm.nih.gov/3202451/


Picture

Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase.
Jacoby DB, Tamaoki J, Borson DB, Nadel JA.J Appl Physiol (1985). 1988 Jun;64(6):2653-8. PMID: 3042736

​pubmed.ncbi.nlm.nih.gov/3042736/


Effect of human eosinophil major basic protein on ion transport in dog tracheal epithelium.
Jacoby DB, Ueki IF, Widdicombe JH, Loegering DA, Gleich GJ, Nadel JA.Am Rev Respir Dis. 1988 Jan;137(1):13-6. PMID: 3422142

​pubmed.ncbi.nlm.nih.gov/3422142/


Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig.
Fryer AD, Maclagan J.Eur J Pharmacol. 1987 Jul 9;139(2):187-91. PMID: 2958300

pubmed.ncbi.nlm.nih.gov/2958300/


Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung.
Fryer AD, Maclagan J.Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):367-71. PMID: 3600815

pubmed.ncbi.nlm.nih.gov/3600815/


Postganglionic muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig.
Faulkner D, Fryer AD, Maclagan J.Br J Pharmacol. 1986 May;88(1):181-7. PMID: 3708215

pubmed.ncbi.nlm.nih.gov/3708215/


Ion transport across cat and ferret tracheal epithelia.
Corrales RJ, Coleman DL, Jacoby DB, Leikauf GD, Hahn HL, Nadel JA, Widdicombe JH.J Appl Physiol (1985). 1986 Sep;61(3):1065-70. PMID: 3759745

pubmed.ncbi.nlm.nih.gov/3759745/


Neuronal muscarinic receptors attenuate vagally-induced contraction of feline bronchial smooth muscle.
Blaber LC, Fryer AD, Maclagan J.Br J Pharmacol. 1985 Nov;86(3):723-8. PMID: 2998526

pubmed.ncbi.nlm.nih.gov/2998526/


The response of cat airways to histamine in vivo and in vitro.
Blaber LC, Fryer AD.Br J Pharmacol. 1985 Feb;84(2):309-16. PMID: 2858235

pubmed.ncbi.nlm.nih.gov/2858235/


Picture

Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig.
Fryer AD, Maclagan J.Br J Pharmacol. 1984 Dec;83(4):973-8. PMID: 6518347

pubmed.ncbi.nlm.nih.gov/6518347/

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